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Effects of alkaline ionized water on formation & maintenance of
osseous tissues
by Rei Takahashi Zhenhua Zhang Yoshinori
Itokawa
(Kyoto University Graduate School of Medicine, Dept. of Pathology and
Tumor Biology, Fukui Prefectural University)
Effects of calcium alkaline ionized water on formation and maintenance of
osseous tissues in rats were examined. In the absence of calcium in the diet, no
apparent calcification was observed with only osteoid formation being prominent.
Striking differences were found among groups that were given diets with 30% and
60% calcium. Rats raised by calcium ionized water showed the least osteogenetic
disturbance. Tibiae and humeri are more susceptible to calcium deficiency than
femora. Theses results may indicate that calcium in drinking water effectively
supplements osteogenesis in case of dietary calcium deficiency. The mechanism
involved in osteoid formation such as absorption rate of calcium from the
intestine and effects of calcium alkaline ionized drinking water on maintaining
bone structure in the process of aging or under the condition of calcium
deficiency is investigated.
Osteoporosis that has lately drawn public attention is defined as "conditions
of bone brittleness caused by reduction in the amount of bone frames and
deterioration of osseous microstructure." Abnormal calcium metabolism has been
considered to be one of the factors to contribute to this problem, which in turn
is caused by insufficient calcium take in, reduction in enteral absorption rate
of calcium and increase in the amount of calcium in urinal discharge. Under
normal conditions, bones absorb old bones by regular metabolism through osteoid
formation to maintain their strength and function as supporting structure. It is
getting clear that remodeling of bones at the tissue level goes through the
process of activation, resorption, reversal, matrix synthesis and
mineralization. Another important function of bones is storing minerals
especially by coordinating with intestines and kidneys to control calcium
concentration in the blood. When something happens to this osteo metabolism, it
results in abnormal morphological changes. Our analyses have been focusing
mostly on the changes in the amount of bones to examine effects of calcium
alkaline ionized water on the reaction system of osteo metabolism and its
efficiency. Ibis time, however, we studied it further from the standpoint of
histology. In other words, we conducted comparative studies on morphological and
kinetic changes of osteogenesis by testing alkaline ionized water, tap water and
solution of lactate on rats.
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